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Agonist activation of α7 nicotinic acetylcholine receptors via an allosteric transmembrane site

Conventional nicotinic acetylcholine receptor (nAChR) agonists, such as acetylcholine, act at an extracellular “orthosteric” binding site located at the interface between two adjacent subunits. Here, we present evidence of potent activation of α7 nAChRs via an allosteric transmembrane site. Previous...

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Bibliografski detalji
Glavni autori: Gill, JasKiran K., Savolainen, Mari, Young, Gareth T., Zwart, Ruud, Sher, Emanuele, Millar, Neil S.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3078348/
https://ncbi.nlm.nih.gov/pubmed/21436053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1017975108
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