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Agonist activation of α7 nicotinic acetylcholine receptors via an allosteric transmembrane site
Conventional nicotinic acetylcholine receptor (nAChR) agonists, such as acetylcholine, act at an extracellular “orthosteric” binding site located at the interface between two adjacent subunits. Here, we present evidence of potent activation of α7 nAChRs via an allosteric transmembrane site. Previous...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3078348/ https://ncbi.nlm.nih.gov/pubmed/21436053 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1017975108 |
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