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A Series of α7 Nicotinic Acetylcholine Receptor Allosteric Modulators with Close Chemical Similarity but Diverse Pharmacological Properties

Acetylcholine activates nicotinic acetylcholine receptors (nAChRs) by binding to an extracellular site located at the interface of two adjacent subunits. In contrast, recent studies have provided evidence that positive allosteric modulators (PAMs) such as TQS (4-(naphthalen-2-yl)-3a,4,5,9b-tetrahydr...

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Détails bibliographiques
Auteurs principaux: Gill, JasKiran K., Dhankher, Persis, Sheppard, Tom D., Sher, Emanuele, Millar, Neil S.
Format: Artigo
Langue:Inglês
Publié: The American Society for Pharmacology and Experimental Therapeutics 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3336803/
https://ncbi.nlm.nih.gov/pubmed/22328718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.111.076026
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