The influence of allosteric modulators and transmembrane mutations on desensitisation and activation of α7 nicotinic acetylcholine receptors

Acetylcholine activates nicotinic acetylcholine receptors (nAChRs) by binding at an extracellular orthosteric site. Previous studies have described several positive allosteric modulators (PAMs) that are selective for homomeric α7 nAChRs. These include type I PAMs, which exert little or no effect on...

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Publicado en:Neuropharmacology
Autores principales: Chatzidaki, Anna, D'Oyley, Jarryl M., Gill-Thind, JasKiran K., Sheppard, Tom D., Millar, Neil S.
Formato: Artigo
Lenguaje:Inglês
Publicado: Pergamon Press 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4548482/
https://ncbi.nlm.nih.gov/pubmed/25998276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2015.05.006
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