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Diversity of Nicotinic Acetylcholine Receptor Positive Allosteric Modulators Revealed by Mutagenesis and a Revised Structural Model

By combining electrophysiological and computational approaches we have examined a series of positive allosteric modulators (PAMs) acting on the human α7 nicotinic acetylcholine receptor (nAChR). Electrophysiological studies have focused on three α7-selective PAMs (A-867744, TBS-516, and TQS) that di...

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Publicat a:Mol Pharmacol
Autors principals: Newcombe, Joseph, Chatzidaki, Anna, Sheppard, Tom D., Topf, Maya, Millar, Neil S.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2018
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5767682/
https://ncbi.nlm.nih.gov/pubmed/29196491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.117.110551
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