Agonist activation of α7 nicotinic acetylcholine receptors via an allosteric transmembrane site

Conventional nicotinic acetylcholine receptor (nAChR) agonists, such as acetylcholine, act at an extracellular “orthosteric” binding site located at the interface between two adjacent subunits. Here, we present evidence of potent activation of α7 nAChRs via an allosteric transmembrane site. Previous...

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Main Authors: Gill, JasKiran K., Savolainen, Mari, Young, Gareth T., Zwart, Ruud, Sher, Emanuele, Millar, Neil S.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2011
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3078348/
https://ncbi.nlm.nih.gov/pubmed/21436053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1017975108
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