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Inhibition of β-Secretase in Vivo via Antibody Binding to Unique Loops (D and F) of BACE1
β-Secretase (BACE1) is an attractive drug target for Alzheimer disease. However, the design of clinical useful inhibitors targeting its active site has been extremely challenging. To identify alternative drug targeting sites we have generated a panel of BACE1 monoclonal antibodies (mAbs) that interf...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3048749/ https://ncbi.nlm.nih.gov/pubmed/21209097 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.194860 |
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