Inhibition of β-Secretase in Vivo via Antibody Binding to Unique Loops (D and F) of BACE1

β-Secretase (BACE1) is an attractive drug target for Alzheimer disease. However, the design of clinical useful inhibitors targeting its active site has been extremely challenging. To identify alternative drug targeting sites we have generated a panel of BACE1 monoclonal antibodies (mAbs) that interf...

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Bibliografiske detaljer
Main Authors: Zhou, Lujia, Chávez-Gutiérrez, Lucia, Bockstael, Katrijn, Sannerud, Ragna, Annaert, Wim, May, Patrick C., Karran, Eric, De Strooper, Bart
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Neurobiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048749/
https://ncbi.nlm.nih.gov/pubmed/21209097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.194860
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