Activation-induced cytidine deaminase induces reproducible DNA breaks at many non-Ig loci in activated B cells

After immunization or infection, activation-induced cytidine deaminase (AID) initiates diversification of immunoglobulin (Ig) genes in B cells, introducing mutations within the antigen binding V regions (somatic hypermutation, SHM) and double-strand DNA breaks (DSBs) into switch (S) regions, leading...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Staszewski, Ori, Baker, Richard E., Ucher, Anna J., Martier, Raygene, Stavnezer, Janet, Guikema, Jeroen E.J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2011
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3044441/
https://ncbi.nlm.nih.gov/pubmed/21255732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.01.007
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