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Activation-induced cytidine deaminase induces reproducible DNA breaks at many non-Ig loci in activated B cells
After immunization or infection, activation-induced cytidine deaminase (AID) initiates diversification of immunoglobulin (Ig) genes in B cells, introducing mutations within the antigen binding V regions (somatic hypermutation, SHM) and double-strand DNA breaks (DSBs) into switch (S) regions, leading...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3044441/ https://ncbi.nlm.nih.gov/pubmed/21255732 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.01.007 |
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