Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genes

Activation-induced cytidine deaminase (AID) is required for both somatic hypermutation and class-switch recombination in activated B cells. AID is also known to target nonimmunoglobulin genes and introduce mutations or chromosomal translocations, eventually causing tumors. To identify as-yet-unknown...

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Bibliographic Details
Main Authors: Kato, Lucia, Begum, Nasim A., Burroughs, A. Maxwell, Doi, Tomomitsu, Kawai, Jun, Daub, Carsten O., Kawaguchi, Takahisa, Matsuda, Fumihiko, Hayashizaki, Yoshihide, Honjo, Tasuku
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2012
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3289292/
https://ncbi.nlm.nih.gov/pubmed/22308462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1120791109
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