Epigenetic targeting of activation-induced cytidine deaminase

Activation-induced cytidine deaminase (AID) initiates class switch recombination (CSR) and somatic hypermutation (SHM) by deaminating cytosine residues in immunoglobulin genes (Igh, Igκ, and Igλ). At a lower frequency, AID also causes collateral DNA damage at non-Ig loci, including genes that are re...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Wang, Qiao, Oliveira, Thiago, Jankovic, Mila, Silva, Israel T., Hakim, Ofir, Yao, Kaihui, Gazumyan, Anna, Mayer, Christian T., Pavri, Rushad, Casellas, Rafael, Nussenzweig, Michel C., Robbiani, Davide F.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4284578/
https://ncbi.nlm.nih.gov/pubmed/25512519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1420575111
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