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Epigenetic targeting of activation-induced cytidine deaminase
Activation-induced cytidine deaminase (AID) initiates class switch recombination (CSR) and somatic hypermutation (SHM) by deaminating cytosine residues in immunoglobulin genes (Igh, Igκ, and Igλ). At a lower frequency, AID also causes collateral DNA damage at non-Ig loci, including genes that are re...
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| 發表在: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2014
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4284578/ https://ncbi.nlm.nih.gov/pubmed/25512519 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1420575111 |
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