Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes

The cytidine deaminase AID hypermutates immunoglobulin genes but can also target oncogenes, leading to tumorigenesis. The extent of AID’s promiscuity and its predilection for immunoglobulin genes are unknown. We report here that AID interacted broadly with promoter-proximal sequences associated with...

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Detaylı Bibliyografya
Asıl Yazarlar: Yamane, Arito, Resch, Wolfgang, Kuo, Nan, Kuchen, Stefan, Li, Zhiyu, Sun, Hong-wei, Robbiani, Davide F, McBride, Kevin, Nussenzweig, Michel C, Casellas, Rafael
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2010
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3005028/
https://ncbi.nlm.nih.gov/pubmed/21113164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1964
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