Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes

The cytidine deaminase AID hypermutates immunoglobulin genes but can also target oncogenes, leading to tumorigenesis. The extent of AID’s promiscuity and its predilection for immunoglobulin genes are unknown. We report here that AID interacted broadly with promoter-proximal sequences associated with...

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Bibliografiska uppgifter
Huvudupphovsmän: Yamane, Arito, Resch, Wolfgang, Kuo, Nan, Kuchen, Stefan, Li, Zhiyu, Sun, Hong-wei, Robbiani, Davide F, McBride, Kevin, Nussenzweig, Michel C, Casellas, Rafael
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3005028/
https://ncbi.nlm.nih.gov/pubmed/21113164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1964
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