RPA accumulation during class switch recombination represents 5′-3′ DNA end resection during the S-G2/M phase of the cell cycle

AID promotes chromosomal translocations by inducing DNA double-strand breaks (DSBs) at immunoglobulin (Ig) genes and oncogenes in G1. RPA is a ssDNA-binding protein that associates with resected DSBs in the S phase and facilitates the assembly of factors involved in homologous repair (HR) such as Ra...

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Detalhes bibliográficos
Main Authors: Yamane, Arito, Robbiani, Davide F., Resch, Wolfgang, Bothmer, Anne, Nakahashi, Hirotaka, Oliveira, Thiago, Rommel, Philipp C., Brown, Eric J., Nussenzweig, Andre, Nussenzweig, Michel C., Casellas, Rafael
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3563767/
https://ncbi.nlm.nih.gov/pubmed/23291097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2012.12.006
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