Rif1 Prevents Resection of DNA Breaks and Promotes Immunoglobulin Class Switching

DNA double-strand breaks (DSBs) represent a threat to the genome because they can lead to loss of genetic information and chromosome rearrangements. The DNA repair protein p53 binding protein 1 (53BP1) protects the genome by limiting nucleolytic processing of DSBs by a mechanism that requires its ph...

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Detalhes bibliográficos
Main Authors: Di Virgilio, Michela, Callen, Elsa, Yamane, Arito, Zhang, Wenzhu, Jankovic, Mila, Gitlin, Alexander D., Feldhahn, Niklas, Resch, Wolfgang, Oliveira, Thiago Y., Chait, Brian T., Nussenzweig, André, Casellas, Rafael, Robbiani, Davide F., Nussenzweig, Michel C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3815530/
https://ncbi.nlm.nih.gov/pubmed/23306439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1230624
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