Translocation-Capture Sequencing Reveals the Extent and Nature of Chromosomal Rearrangements in B Lymphocytes

Chromosomal rearrangements, including translocations, require formation and joining of DNA double strand breaks (DSBs). These events disrupt the integrity of the genome and are frequently involved in producing leukemias, lymphomas and sarcomas. Despite the importance of these events, current underst...

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Autors principals: Klein, Isaac A., Resch, Wolfgang, Jankovic, Mila, Oliveira, Thiago, Yamane, Arito, Nakahashi, Hirotaka, Di Virgilio, Michela, Bothmer, Anne, Nussenzweig, Andre, Robbiani, Davide F., Casellas, Rafael, Nussenzweig, Michel C.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190307/
https://ncbi.nlm.nih.gov/pubmed/21962510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.07.048
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