DNA damage defines sites of recurrent chromosomal translocations in B lymphocytes

Recurrent chromosomal translocations underlie both haematopoietic and solid tumours. Their origin has been ascribed to selection of random rearrangements, targeted DNA damage, or frequent nuclear interactions between translocation partners; however, the relative contribution of each of these element...

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Main Authors: Hakim, Ofir, Resch, Wolfgang, Yamane, Arito, Klein, Isaac, Kieffer-Kwon, Kyong-Rim, Jankovic, Mila, Oliveira, Thiago, Bothmer, Anne, Voss, Ty C., Ansarah-Sobrinho, Camilo, Mathe, Ewy, Liang, Genqing, Cobell, Jesse, Nakahashi, Hirotaka, Robbiani, Davide F., Nussenzweig, Andre, Hager, Gordon L., Nussenzweig, Michel C., Casellas, Rafael
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3459314/
https://ncbi.nlm.nih.gov/pubmed/22314321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10909
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