53BP1 alters the landscape of DNA rearrangements and suppresses AID-induced B cell lymphoma

Deficiencies in factors that regulate the DNA damage response enhance the incidence of malignancy by destabilizing the genome. However, the precise influence of the DNA damage response on regulation of cancer-associated rearrangements is not well defined. Here we examine the genome-wide impact of tu...

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Autori principali: Jankovic, Mila, Feldhahn, Niklas, Oliveira, Thiago Y., Silva, Israel T., Kieffer-Kwon, Kyong-rim, Yamane, Arito, Resch, Wolfgang, Klein, Isaac, Robbiani, Davide F., Casellas, Rafael, Nussenzweig, Michel C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3658150/
https://ncbi.nlm.nih.gov/pubmed/23290917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.11.029
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