Fate Mapping for Activation-Induced Cytidine Deaminase (AID) Marks Non-Lymphoid Cells During Mouse Development

The Aicda gene encodes Activation-Induced cytidine Deaminase (AID), an enzyme essential for remodeling antibody genes in mature B lymphocytes. AID is also responsible for DNA damage at oncogenes, leading to their mutation and cancer-associated chromosome translocation in lymphoma. We used fate mappi...

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Detalhes bibliográficos
Main Authors: Rommel, Philipp C., Bosque, David, Gitlin, Alexander D., Croft, Gist F., Heintz, Nathaniel, Casellas, Rafael, Nussenzweig, Michel C., Kriaucionis, Skirmantas, Robbiani, Davide F.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3704518/
https://ncbi.nlm.nih.gov/pubmed/23861962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0069208
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