Regulation of hypermutation by activation-induced cytidine deaminase phosphorylation

Activation-induced cytidine deaminase (AID) initiates Ig class switch recombination and somatic hypermutation by producing U:G mismatches in DNA. These mismatches also have the potential to induce DNA damage including double-stranded breaks and chromosome translocations; therefore, strict regulation...

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Bibliografische gegevens
Hoofdauteurs: McBride, Kevin M., Gazumyan, Anna, Woo, Eileen M., Barreto, Vasco M., Robbiani, Davide F., Chait, Brian T., Nussenzweig, Michel C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2006
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1482658/
https://ncbi.nlm.nih.gov/pubmed/16723391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603272103
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