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Regulation of hypermutation by activation-induced cytidine deaminase phosphorylation
Activation-induced cytidine deaminase (AID) initiates Ig class switch recombination and somatic hypermutation by producing U:G mismatches in DNA. These mismatches also have the potential to induce DNA damage including double-stranded breaks and chromosome translocations; therefore, strict regulation...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2006
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1482658/ https://ncbi.nlm.nih.gov/pubmed/16723391 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603272103 |
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