Amino-Terminal Phosphorylation of Activation-Induced Cytidine Deaminase Suppresses c-myc/IgH Translocation

Activation-induced cytidine deaminase (AID) is a mutator enzyme that initiates class switch recombination and somatic hypermutation of immunoglobulin genes (Ig) in B lymphocytes. However, AID also produces off-target DNA damage, including mutations in oncogenes and double-stranded breaks that can se...

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Hlavní autoři: Gazumyan, Anna, Timachova, Ksenia, Yuen, Grace, Siden, Edward, Di Virgilio, Michela, Woo, Eileen M., Chait, Brian T., Reina San-Martin, Bernardo, Nussenzweig, Michel C., McBride, Kevin M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3028632/
https://ncbi.nlm.nih.gov/pubmed/21135131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00349-10
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