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Activation Induced Deaminase is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations
Chromosomal translocation requires formation of paired double strand DNA breaks (DSBs) on heterologous chromosomes. One of the most well characterized oncogenic translocations juxtaposes c-myc and the immunoglobulin heavy chain locus (IgH) and is found in Burkitt’s lymphomas in humans and plasmacyto...
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| Autori principali: | , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2713603/ https://ncbi.nlm.nih.gov/pubmed/19070574 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.09.062 |
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