Activation Induced Deaminase is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations

Chromosomal translocation requires formation of paired double strand DNA breaks (DSBs) on heterologous chromosomes. One of the most well characterized oncogenic translocations juxtaposes c-myc and the immunoglobulin heavy chain locus (IgH) and is found in Burkitt’s lymphomas in humans and plasmacyto...

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Autores principales: Robbiani, Davide F., Bothmer, Anne, Callen, Elsa, Reina-San-Martin, Bernardo, Dorsett, Yair, Difilippantonio, Simone, Bolland, Daniel J., Chen, Hua Tang, Corcoran, Anne E., Nussenzweig, André, Nussenzweig, Michel C.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2713603/
https://ncbi.nlm.nih.gov/pubmed/19070574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.09.062
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