Activation Induced Deaminase is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations

Chromosomal translocation requires formation of paired double strand DNA breaks (DSBs) on heterologous chromosomes. One of the most well characterized oncogenic translocations juxtaposes c-myc and the immunoglobulin heavy chain locus (IgH) and is found in Burkitt’s lymphomas in humans and plasmacyto...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Robbiani, Davide F., Bothmer, Anne, Callen, Elsa, Reina-San-Martin, Bernardo, Dorsett, Yair, Difilippantonio, Simone, Bolland, Daniel J., Chen, Hua Tang, Corcoran, Anne E., Nussenzweig, André, Nussenzweig, Michel C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2713603/
https://ncbi.nlm.nih.gov/pubmed/19070574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.09.062
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky