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Regulation of class switch recombination and somatic mutation by AID phosphorylation
Activation-induced cytidine deaminase (AID) is a mutator enzyme that initiates somatic mutation and class switch recombination in B lymphocytes by introducing uracil:guanine mismatches into DNA. Repair pathways process these mismatches to produce point mutations in the Ig variable region or double-s...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2571933/ https://ncbi.nlm.nih.gov/pubmed/18838546 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20081319 |
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