Regulation of class switch recombination and somatic mutation by AID phosphorylation

Activation-induced cytidine deaminase (AID) is a mutator enzyme that initiates somatic mutation and class switch recombination in B lymphocytes by introducing uracil:guanine mismatches into DNA. Repair pathways process these mismatches to produce point mutations in the Ig variable region or double-s...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: McBride, Kevin M., Gazumyan, Anna, Woo, Eileen M., Schwickert, Tanja A., Chait, Brian T., Nussenzweig, Michel C.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The Rockefeller University Press 2008
Gaiak:
Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2571933/
https://ncbi.nlm.nih.gov/pubmed/18838546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20081319
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