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AID phosphorylation regulates mismatch repair-dependent class switch recombination and affinity maturation
Activation-induced cytidine deaminase (AID) generates U:G mismatches in immunoglobulin genes that can be converted into untemplated mutations during somatic hypermutation (SHM) or DNA double-strand breaks (DSB) during class switch recombination (CSR). Null mutations in UNG and MSH2 demonstrate the c...
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| Publicado no: | J Immunol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6920541/ https://ncbi.nlm.nih.gov/pubmed/31757865 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1900809 |
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