Phosphorylation promotes activation-induced cytidine deaminase activity at the Myc oncogene

Activation-induced cytidine deaminase (AID) is a mutator enzyme that targets immunoglobulin (Ig) genes to initiate antibody somatic hypermutation (SHM) and class switch recombination (CSR). Off-target AID association also occurs, which causes oncogenic mutations and chromosome rearrangements. Howeve...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Exp Med
Egile Nagusiak: Mu, Yunxiang, Zelazowska, Monika A., McBride, Kevin M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The Rockefeller University Press 2017
Gaiak:
Research Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5716038/
https://ncbi.nlm.nih.gov/pubmed/29122947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20170468
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