Impact of Phosphorylation and Phosphorylation-null Mutants on the Activity and Deamination Specificity of Activation-induced Cytidine Deaminase

Activation-induced cytidine deaminase (AID) initiates somatic hypermutation and class switch recombination in B cells by deaminating C → U on transcribed DNA. Here we analyze the role of phosphorylation and phosphorylation-null mutants on the biochemical behavior of AID, including enzyme specific ac...

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Autors principals: Pham, Phuong, Smolka, Marcus B., Calabrese, Peter, Landolph, Alice, Zhang, Ke, Zhou, Huilin, Goodman, Myron F.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2008
Matèries:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2427360/
https://ncbi.nlm.nih.gov/pubmed/18417471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802121200
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