Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase

The expression of activation-induced cytidine deaminase (AID) is prerequisite to a “trifecta” of key molecular events in B cells: class-switch recombination and somatic hypermutation in humans and mice and gene conversion in chickens. Although this critically important enzyme shares common sequence...

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Hlavní autoři: Bransteitter, Ronda, Pham, Phuong, Scharff, Matthew D., Goodman, Myron F.
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 2003
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC153055/
https://ncbi.nlm.nih.gov/pubmed/12651944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0730835100
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