Analysis of a Single-stranded DNA-scanning Process in Which Activation-induced Deoxycytidine Deaminase (AID) Deaminates C to U Haphazardly and Inefficiently to Ensure Mutational Diversity

Enzymes that scan single-stranded (ss) DNA have been studied far less extensively than those that scan double-stranded (ds) DNA. Activation-induced deoxycytidine deaminase (AID) deaminates C to U on single-stranded DNA to initiate immunological diversity. Except for processive deaminations favoring...

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Bibliographic Details
Main Authors: Pham, Phuong, Calabrese, Peter, Park, Soo Jung, Goodman, Myron F.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Enzymology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137067/
https://ncbi.nlm.nih.gov/pubmed/21572036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.241208
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