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AID and Apobec3G haphazard deamination and mutational diversity
Activation-induced deoxycytidine deaminase (AID) and Apobec 3G (Apo3G) cause mutational diversity by initiating mutations on regions of single-stranded (ss) DNA. Expressed in B cells, AID deaminates C → U in actively transcribed immunoglobulin (Ig) variable and switch regions to initiate the somatic...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2012
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3600397/ https://ncbi.nlm.nih.gov/pubmed/23178850 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-012-1212-1 |
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