Phosphorylation promotes activation-induced cytidine deaminase activity at the Myc oncogene

Activation-induced cytidine deaminase (AID) is a mutator enzyme that targets immunoglobulin (Ig) genes to initiate antibody somatic hypermutation (SHM) and class switch recombination (CSR). Off-target AID association also occurs, which causes oncogenic mutations and chromosome rearrangements. Howeve...

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Bibliographic Details
Published in:J Exp Med
Main Authors: Mu, Yunxiang, Zelazowska, Monika A., McBride, Kevin M.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2017
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5716038/
https://ncbi.nlm.nih.gov/pubmed/29122947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20170468
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