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Phosphorylation promotes activation-induced cytidine deaminase activity at the Myc oncogene
Activation-induced cytidine deaminase (AID) is a mutator enzyme that targets immunoglobulin (Ig) genes to initiate antibody somatic hypermutation (SHM) and class switch recombination (CSR). Off-target AID association also occurs, which causes oncogenic mutations and chromosome rearrangements. Howeve...
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| Udgivet i: | J Exp Med |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Rockefeller University Press
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5716038/ https://ncbi.nlm.nih.gov/pubmed/29122947 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20170468 |
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