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Somatic Hypermutation Is Limited by CRM1-dependent Nuclear Export of Activation-induced Deaminase
Somatic hypermutation (SHM) and class switch recombination (CSR) are initiated in activated B lymphocytes by activation-induced deaminase (AID). AID is thought to make lesions in DNA by deaminating cytidine residues in single-stranded DNA exposed by RNA polymerase during transcription. Although this...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The Rockefeller University Press
2004
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2211910/ https://ncbi.nlm.nih.gov/pubmed/15117971 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20040373 |
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