Somatic hypermutation of human mitochondrial and nuclear DNA by APOBEC3 cytidine deaminases, a pathway for DNA catabolism

The human APOBEC3 (A3A–A3H) locus encodes six cytidine deaminases that edit single-stranded DNA, the result being DNA peppered with uridine. Although several cytidine deaminases are clearly restriction factors for retroviruses and hepadnaviruses, it is not known if APOBEC3 enzymes have roles outside...

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Detalhes bibliográficos
Main Authors: Suspène, Rodolphe, Aynaud, Marie-Ming, Guétard, Denise, Henry, Michel, Eckhoff, Grace, Marchio, Agnès, Pineau, Pascal, Dejean, Anne, Vartanian, Jean-Pierre, Wain-Hobson, Simon
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064337/
https://ncbi.nlm.nih.gov/pubmed/21368204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1009687108
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