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Efficient Deamination of 5-Methylcytidine and 5-Substituted Cytidine Residues in DNA by Human APOBEC3A Cytidine Deaminase

Deamination of 5-methylcytidine (5MeC) in DNA results in a G:T mismatch unlike cytidine (C) deamination which gives rise to a G:U pair. Deamination of C was generally considered to arise spontaneously. It is now clear that human APOBEC3A (A3A), a polynucleotide cytidine deaminase (PCD) with specific...

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Bibliografiset tiedot
Päätekijät: Suspène, Rodolphe, Aynaud, Marie-Ming, Vartanian, Jean-Pierre, Wain-Hobson, Simon
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2013
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3688686/
https://ncbi.nlm.nih.gov/pubmed/23840298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0063461
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