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Human Tribbles 3 Protects Nuclear DNA from Cytidine Deamination by APOBEC3A
The human polydeoxynucleotide cytidine deaminases APOBEC3A, APOBEC3C, and APOBEC3H are capable of mutating viral DNA in the nucleus, whereas APOBEC3A alone efficiently edits nuclear DNA. Deamination is rapidly followed by excision of uracil residues and can lead to double-stranded breaks. It is not...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3493958/ https://ncbi.nlm.nih.gov/pubmed/22977230 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.372722 |
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