Mouse APOBEC1 cytidine deaminase can induce somatic mutations in chromosomal DNA

Abstract Background APOBEC1 (A1) enzymes are cytidine deaminases involved in RNA editing. In addition to this activity, a few A1 enzymes have been shown to be active on single stranded DNA. As two human ssDNA cytidine deaminases APOBEC3A (A3A), APOBEC3B (A3B) and related enzymes across the spectrum...

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Detalhes bibliográficos
Main Authors: Vincent Caval, Wenjuan Jiao, Noémie Berry, Pierre Khalfi, Emmanuelle Pitré, Valérie Thiers, Jean-Pierre Vartanian, Simon Wain-Hobson, Rodolphe Suspène
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2019-11-01
Colecção:BMC Genomics
Assuntos:
APOBEC1
Cytidine deaminase
Somatic mutations
Nuclear DNA
Cancer
Acesso em linha:http://link.springer.com/article/10.1186/s12864-019-6216-x
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