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A broad atlas of somatic hypermutation allows prediction of activation-induced deaminase targets
Activation-induced deaminase (AID) initiates antibody diversification in germinal center (GC) B cells through the deamination of cytosines on immunoglobulin genes. AID can also target other regions in the genome, triggering mutations or chromosome translocations, with major implications for oncogeni...
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| Publicado no: | J Exp Med |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Rockefeller University Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5839764/ https://ncbi.nlm.nih.gov/pubmed/29374026 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20171738 |
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