A broad atlas of somatic hypermutation allows prediction of activation-induced deaminase targets

Activation-induced deaminase (AID) initiates antibody diversification in germinal center (GC) B cells through the deamination of cytosines on immunoglobulin genes. AID can also target other regions in the genome, triggering mutations or chromosome translocations, with major implications for oncogeni...

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Dades bibliogràfiques
Publicat a:J Exp Med
Autors principals: Álvarez-Prado, Ángel F., Pérez-Durán, Pablo, Pérez-García, Arantxa, Benguria, Alberto, Torroja, Carlos, de Yébenes, Virginia G., Ramiro, Almudena R.
Format: Artigo
Idioma:Inglês
Publicat: Rockefeller University Press 2018
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5839764/
https://ncbi.nlm.nih.gov/pubmed/29374026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20171738
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