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UNG shapes the specificity of AID-induced somatic hypermutation
Secondary diversification of antibodies through somatic hypermutation (SHM) and class switch recombination (CSR) is a critical component of the immune response. Activation-induced deaminase (AID) initiates both processes by deaminating cytosine residues in immunoglobulin genes. The resulting U:G mis...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3405504/ https://ncbi.nlm.nih.gov/pubmed/22665573 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20112253 |
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