UNG shapes the specificity of AID-induced somatic hypermutation

Secondary diversification of antibodies through somatic hypermutation (SHM) and class switch recombination (CSR) is a critical component of the immune response. Activation-induced deaminase (AID) initiates both processes by deaminating cytosine residues in immunoglobulin genes. The resulting U:G mis...

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Autori principali: Pérez-Durán, Pablo, Belver, Laura, de Yébenes, Virginia G., Delgado, Pilar, Pisano, David G., Ramiro, Almudena R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3405504/
https://ncbi.nlm.nih.gov/pubmed/22665573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20112253
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