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The Activation-induced Deaminase Functions in a Postcleavage Step of the Somatic Hypermutation Process
Activation of B cells by antigen fuels two distinct molecular modifications of immunoglobulin (Ig) genes. Class-switch recombination (CSR) replaces the Igμ heavy chain constant region with a downstream constant region gene, thereby altering the effector function of the resulting antibodies. Somatic...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The Rockefeller University Press
2002
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2193708/ https://ncbi.nlm.nih.gov/pubmed/11994424 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20011858 |
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