Characterization of immunoglobulin gene somatic hypermutation in the absence of activation-induced cytidine deaminase

Somatic hypermutation (SHM) of Ig genes depends upon the deamination of C nucleotides in WRCY (W=A/T, R=A/G, Y=C/T) motifs by activation-induced cytidine deaminase (AICDA). Despite this, a large number of mutations occur in WA motifs that can be accounted for by the activity of polymerase eta (POL η...

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Hlavní autoři: Longo, Nancy S., Satorius, Colleen L., Plebani, Alessandro, Durandy, Anne, Lipsky, Peter E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587332/
https://ncbi.nlm.nih.gov/pubmed/18606684
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