Immunization of mice with pneumolysin toxoid confers a significant degree of protection against at least nine serotypes of Streptococcus pneumoniae.

Pneumolysin is the thiol-activated cytolysin produced by Streptococcus pneumoniae. Mice were immunized with a genetically engineered toxoid version of pneumolysin, which was derived from a serotype 2 pneumococcus. The toxoid carried the mutation Trp-433-->Phe. Alum was used as the adjuvant. Immunize...

Descripción completa

Detalles Bibliográficos

Publicado en:	Infect Immun
Autores principales:	Alexander, J E, Lock, R A, Peeters, C C, Poolman, J T, Andrew, P W, Mitchell, T J, Hansman, D, Paton, J C
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 1994
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC303321/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7960154/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.62.12.5683-5688.1994
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!