Effect of defined point mutations in the pneumolysin gene on the virulence of Streptococcus pneumoniae.

The thiol-activated toxin pneumolysin is a known pneumococcal virulence factor, with both cytotoxic (hemolytic) and complement activation properties. Copies of the pneumolysin gene carrying defined point mutations affecting either or both of these properties were introduced into the chromosome of St...

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Bibliografiske detaljer

Udgivet i:	Infect Immun
Principais autores:	Berry, A M, Alexander, J E, Mitchell, T J, Andrew, P W, Hansman, D, Paton, J C
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 1995
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC173251/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7729909/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.63.5.1969-1974.1995
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