Effect of defined point mutations in the pneumolysin gene on the virulence of Streptococcus pneumoniae.
The thiol-activated toxin pneumolysin is a known pneumococcal virulence factor, with both cytotoxic (hemolytic) and complement activation properties. Copies of the pneumolysin gene carrying defined point mutations affecting either or both of these properties were introduced into the chromosome of St...
Guardat en:
| Publicat a: | Infect Immun |
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| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology (ASM)
1995
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC173251/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7729909/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.63.5.1969-1974.1995 |
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