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Effect of defined point mutations in the pneumolysin gene on the virulence of Streptococcus pneumoniae.

The thiol-activated toxin pneumolysin is a known pneumococcal virulence factor, with both cytotoxic (hemolytic) and complement activation properties. Copies of the pneumolysin gene carrying defined point mutations affecting either or both of these properties were introduced into the chromosome of St...

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Sábháilte in:
Sonraí bibleagrafaíochta
Foilsithe in:Infect Immun
Príomhchruthaitheoirí: Berry, A M, Alexander, J E, Mitchell, T J, Andrew, P W, Hansman, D, Paton, J C
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: American Society for Microbiology (ASM) 1995
Ábhair:
Rochtain ar líne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC173251/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7729909/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.63.5.1969-1974.1995
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