Immunization of mice with pneumolysin toxoid confers a significant degree of protection against at least nine serotypes of Streptococcus pneumoniae.

Pneumolysin is the thiol-activated cytolysin produced by Streptococcus pneumoniae. Mice were immunized with a genetically engineered toxoid version of pneumolysin, which was derived from a serotype 2 pneumococcus. The toxoid carried the mutation Trp-433-->Phe. Alum was used as the adjuvant. Immun...

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Detalhes bibliográficos
Main Authors: Alexander, J E, Lock, R A, Peeters, C C, Poolman, J T, Andrew, P W, Mitchell, T J, Hansman, D, Paton, J C
Formato: Artigo
Idioma:Inglês
Publicado em: 1994
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC303321/
https://ncbi.nlm.nih.gov/pubmed/7960154
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