Effect of immunization with pneumolysin on survival time of mice challenged with Streptococcus pneumoniae.

The role of the cytolytic toxin pneumolysin in the pathogenicity of Streptococcus pneumoniae was investigated. Pneumolysin was purified to homogeneity and used to immunize mice. When these mice were subsequently challenged via the nasal route with virulent S. pneumoniae, they survived significantly...

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Bibliographic Details
Published in:Infect Immun
Main Authors: Paton, J C, Lock, R A, Hansman, D J
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 1983
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC264890/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6840851/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.40.2.548-552.1983
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