Purification and immunogenicity of genetically obtained pneumolysin toxoids and their conjugation to Streptococcus pneumoniae type 19F polysaccharide.

As part of an ongoing study concerned with improving human vaccines against Streptococcus pneumoniae, the genes for two defined pneumolysin (PL) toxoids (pneumolysoids), Pd-A (PL with a Cys----Gly substitution at amino acid 428) and Pd-B (PL with a Trp----Phe substitution at position 433), were inse...

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Autores principales: Paton, J C, Lock, R A, Lee, C J, Li, J P, Berry, A M, Mitchell, T J, Andrew, P W, Hansman, D, Boulnois, G J
Formato: Artigo
Lenguaje:Inglês
Publicado: 1991
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC258010/
https://ncbi.nlm.nih.gov/pubmed/2050399
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