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Reduced virulence of a defined pneumolysin-negative mutant of Streptococcus pneumoniae.

Insertion-duplication mutagenesis was used to construct a pneumolysin-negative derivative of Streptococcus pneumoniae. This was achieved by first transforming the nonencapsulated strain Rx1 with a derivative of the vector pVA891 carrying a 690-base-pair DNA fragment from the middle of the pneumolysi...

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Detalhes bibliográficos
Main Authors: Berry, A M, Yother, J, Briles, D E, Hansman, D, Paton, J C
Formato: Artigo
Idioma:Inglês
Publicado em: 1989
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC313838/
https://ncbi.nlm.nih.gov/pubmed/2731982
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