Reduced virulence of a defined pneumolysin-negative mutant of Streptococcus pneumoniae.

Insertion-duplication mutagenesis was used to construct a pneumolysin-negative derivative of Streptococcus pneumoniae. This was achieved by first transforming the nonencapsulated strain Rx1 with a derivative of the vector pVA891 carrying a 690-base-pair DNA fragment from the middle of the pneumolysi...

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Bibliografiske detaljer

Udgivet i:	Infect Immun
Principais autores:	Berry, A M, Yother, J, Briles, D E, Hansman, D, Paton, J C
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 1989
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC313838/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2731982/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.57.7.2037-2042.1989
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